|
rs397507444
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
While the A1298C polymorphism showed no measurable association with the overall risk of colorectal cancer, the 1298CC genotype was associated with a statistically significant increase in the risk when alcohol consumption was high, and was also associated with an approximately 2-fold increase in the risk of each of proximal and distal colon cancer.
|
15546509 |
2004 |
|
rs397507444
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Whereas our results do not support an association of high enzyme activity and increased risk of colorectal cancer in general, we can not exclude an association of patients with hereditary disease and the MTHFR 1298A --> C variant.
|
12618331 |
2003 |
|
rs1217691063
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
When MTHFR C677T genotype frequencies in MSS CRC cases were compared to controls, individuals with homozygous variant genotype were at 19% reduced risk of cancer compared to wild type (OR = 0.81; 95% CI: 0.65-1.02).
|
17350979 |
2007 |
|
rs397507444
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We report a population-based case-control study of folate intake, related dietary factors and MTHFR polymorphisms (C677T, A1298C) and colorectal cancer in a population with relatively high colorectal cancer incidence and relatively low folate intake.
|
18053312 |
2008 |
|
rs1217691063
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We report a population-based case-control study of folate intake, related dietary factors and MTHFR polymorphisms (C677T, A1298C) and colorectal cancer in a population with relatively high colorectal cancer incidence and relatively low folate intake.
|
18053312 |
2008 |
|
rs397507444
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We related prediagnostic plasma folate, vitamin B12, and total homocysteine concentrations, and the MTHFR 677C>T and 1298A>C polymorphisms, to the risk of colorectal cancer with and without the CpG island methylator phenotype (CIMP).
|
20012180 |
2010 |
|
rs397507444
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We made a case-control study to analyze a possible association of MTHFR gene polymorphisms C677T and A1298C with risk for colorectal cancer in an eastern Chinese Han population of 137 patients with a confirmed histopathological diagnosis of CRC and 145 age- and gender-matched controls with no history of cancer.
|
22194208 |
2011 |
|
rs1217691063
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We made a case-control study to analyze a possible association of MTHFR gene polymorphisms C677T and A1298C with risk for colorectal cancer in an eastern Chinese Han population of 137 patients with a confirmed histopathological diagnosis of CRC and 145 age- and gender-matched controls with no history of cancer.
|
22194208 |
2011 |
|
rs397507444
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the association of C677T and A1298C, two common polymorphisms in the methylenetetrahydrofolate reductase gene, with risk for early onset colorectal cancer in Lynch syndrome.
|
17855693 |
2007 |
|
rs1217691063
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the association between folate and alcohol intake, methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, and CRC risk in Koreans.
|
22218157 |
2012 |
|
rs397507444
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We here aimed to investigate two common polymorphisms, C677T and A1298C, with genotype and haplotype frequencies in colorectal cancer (CRC) cases among Jordanian.
|
24083702 |
2013 |
|
rs1801131
|
|
Colorectal Carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
We genotyped MTHFR polymorphisms C677T (rs1801133) and A1298C (rs1801131) for 498 CRC patients treated with 5-FU-based chemotherapy after receiving surgery.
|
28044213 |
2017 |
|
rs1801133
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We genotyped MTHFR polymorphisms C677T (rs1801133) and A1298C (rs1801131) for 498 CRC patients treated with 5-FU-based chemotherapy after receiving surgery.
|
28044213 |
2017 |
|
rs1217691063
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found that the MTHFR C677T polymorphism was associated with colorectal cancer (P<0.04) but not with gastric cancer.
|
27823653 |
2016 |
|
rs1217691063
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found that the 677 C>T polymorphism in the MTHFR gene significantly decreased the risk for colorectal cancer in homozygous carriers of the variant allele (OR, 0.58; 95% CI, 0.39-0.87).
|
21211571 |
2011 |
|
rs397507444
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We evaluated the associations between plasma folate, MTHFR C677T, and A1298C, and colorectal cancer in three large prospective studies: the Nurses' Health Study, the Health Professionals Follow-up Study, and the Physicians' Health Study.
|
22367721 |
2012 |
|
rs1217691063
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We evaluated the associations between plasma folate, MTHFR C677T, and A1298C, and colorectal cancer in three large prospective studies: the Nurses' Health Study, the Health Professionals Follow-up Study, and the Physicians' Health Study.
|
22367721 |
2012 |
|
rs1217691063
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that the MTHFR C677T polymorphism slightly increases the risk for colorectal cancer development in our ethnic Kashmir population.
|
21732284 |
2011 |
|
rs397507444
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that the MTHFR 1298A>C polymorphism is a less substantial independent risk factor for colorectal cancer compared to the 677C>T polymorphism.
|
12042673 |
2002 |
|
rs1217691063
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that the MTHFR 1298A>C polymorphism is a less substantial independent risk factor for colorectal cancer compared to the 677C>T polymorphism.
|
12042673 |
2002 |
|
rs1217691063
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We also observed no significant interactions between the MTHFR C677T polymorphism and smoking or drinking in the risk of gastric and colorectal cancer.
|
20504332 |
2010 |
|
rs1217691063
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We aimed to test the hypothesis that the C677T genotype is involved in colorectal cancer.
|
20066895 |
2009 |
|
rs1217691063
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We aimed to test the hypothesis that C677T and A1298C variants of MTHFR predispose to microsatellite instable (MSI) colorectal cancer.
|
20193847 |
2010 |
|
rs1476413
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Using a nondominant model, the AA genotype for MTHFR rs1476413 exhibited a marginally significant (OR = 1.56; 95% CI = 1.00-2.44) association with CRC.
|
23893618 |
2013 |
|
rs397507444
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two common single nucleotide polymorphisms (SNPs) located within the MTHFR gene, 677 C>T and 1298 A>C, that alter the function of the encoded protein have been the focus of many studies on CRC risk outside the context of an inherited predisposition to disease.
|
19156174 |
2009 |